Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells
Identifieur interne : 000D72 ( Main/Exploration ); précédent : 000D71; suivant : 000D73Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells
Auteurs : Michael Roth ; Lei Fang ; Daiana Stolz ; Michael TammSource :
- PLoS ONE [ 1932-6203 ] ; 2019.
Abstract
Bronchial epithelial cells are the first target cell for rhinovirus infection. The course of viral infections in patients with acute bronchitis, asthma and COPD can be improved by oral application of
Url:
DOI: 10.1371/journal.pone.0210702
PubMed: 30707726
PubMed Central: 6358071
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Pelargonium sidoides</italic> radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells</title><author><name sortKey="Roth, Michael" sort="Roth, Michael" uniqKey="Roth M" first="Michael" last="Roth">Michael Roth</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Fang, Lei" sort="Fang, Lei" uniqKey="Fang L" first="Lei" last="Fang">Lei Fang</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Stolz, Daiana" sort="Stolz, Daiana" uniqKey="Stolz D" first="Daiana" last="Stolz">Daiana Stolz</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Tamm, Michael" sort="Tamm, Michael" uniqKey="Tamm M" first="Michael" last="Tamm">Michael Tamm</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30707726</idno><idno type="pmc">6358071</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358071</idno><idno type="RBID">PMC:6358071</idno><idno type="doi">10.1371/journal.pone.0210702</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000999</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000999</idno><idno type="wicri:Area/Pmc/Curation">000999</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000999</idno><idno type="wicri:Area/Pmc/Checkpoint">000281</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000281</idno><idno type="wicri:Area/Ncbi/Merge">000842</idno><idno type="wicri:Area/Ncbi/Curation">000842</idno><idno type="wicri:Area/Ncbi/Checkpoint">000842</idno><idno type="wicri:Area/Main/Merge">000D74</idno><idno type="wicri:Area/Main/Curation">000D72</idno><idno type="wicri:Area/Main/Exploration">000D72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Pelargonium sidoides</italic> radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells</title><author><name sortKey="Roth, Michael" sort="Roth, Michael" uniqKey="Roth M" first="Michael" last="Roth">Michael Roth</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Fang, Lei" sort="Fang, Lei" uniqKey="Fang L" first="Lei" last="Fang">Lei Fang</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Stolz, Daiana" sort="Stolz, Daiana" uniqKey="Stolz D" first="Daiana" last="Stolz">Daiana Stolz</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Tamm, Michael" sort="Tamm, Michael" uniqKey="Tamm M" first="Michael" last="Tamm">Michael Tamm</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bronchial epithelial cells are the first target cell for rhinovirus infection. The course of viral infections in patients with acute bronchitis, asthma and COPD can be improved by oral application of <italic>Pelargonium sidoides</italic> radix extract; however, the mechanism is not well understood. This study investigated the <italic>in vitro</italic> effect of <italic>Pelargonium sidoides</italic> radix extract (EPs 7630) on the expression of virus binding cell membrane and host defence supporting proteins on primary human bronchial epithelial cells (hBEC). Cells were isolated from patients with severe asthma (n = 6), moderate COPD (n = 6) and non-diseased controls (n = 6). Protein expression was determined by Western-blot and immunofluorescence. Rhinovirus infection was determined by immunofluorescence as well as by polymerase chain reaction. Cell survival was determined by manual cell count after live/death immunofluorescence staining. All parameters were determined over a period of 3 days. The results show that EPs 7630 concentration-dependently and significantly increased hBEC survival after rhinovirus infection. This effect was paralleled by decreased expression of the inducible co-stimulator (ICOS), its ligand ICOSL and cell surface calreticulin (C1qR). In contrast, EPs 7630 up-regulated the expression of the host defence supporting proteins β-defensin-1 and SOCS-1, both in rhinovirus infected and un-infected hBEC. The expression of other virus interacting cell membrane proteins such as MyD88, TRL2/4 or ICAM-1 was not altered by EPs 7630. The results indicate that EPs 7630 may reduce rhinovirus infection of human primary BEC by down-regulating cell membrane docking proteins and up-regulating host defence proteins.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Looi, K" uniqKey="Looi K">K Looi</name></author><author><name sortKey="Buckley, Ag" uniqKey="Buckley A">AG Buckley</name></author><author><name sortKey="Rigby, Pj" uniqKey="Rigby P">PJ Rigby</name></author><author><name sortKey="Garratt, Lw" uniqKey="Garratt L">LW Garratt</name></author><author><name sortKey="Iosifidis, T" uniqKey="Iosifidis T">T Iosifidis</name></author><author><name sortKey="Zosky, Gr" uniqKey="Zosky G">GR Zosky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilkinson, Tma" uniqKey="Wilkinson T">TMA Wilkinson</name></author><author><name sortKey="Aris, E" uniqKey="Aris E">E Aris</name></author><author><name sortKey="Bourne, S" uniqKey="Bourne S">S 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uniqKey="Dowran R">R Dowran</name></author><author><name sortKey="Sarvari, J" uniqKey="Sarvari J">J Sarvari</name></author><author><name sortKey="Moattari, A" uniqKey="Moattari A">A Moattari</name></author><author><name sortKey="Fattahi, Mr" uniqKey="Fattahi M">MR Fattahi</name></author><author><name sortKey="Ramezani, A" uniqKey="Ramezani A">A Ramezani</name></author><author><name sortKey="Hosseini, Sy" uniqKey="Hosseini S">SY Hosseini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obajemu, Aa" uniqKey="Obajemu A">AA Obajemu</name></author><author><name sortKey="Rao, N" uniqKey="Rao N">N Rao</name></author><author><name sortKey="Dilley, Ka" uniqKey="Dilley K">KA Dilley</name></author><author><name sortKey="Vargas, Jm" uniqKey="Vargas J">JM Vargas</name></author><author><name sortKey="Sheikh, F" uniqKey="Sheikh F">F Sheikh</name></author><author><name sortKey="Donnelly, Rp" uniqKey="Donnelly R">RP 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Zhang</name></author><author><name sortKey="Sunkara, L T" uniqKey="Sunkara L">L.T. Sunkara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalenik, Bm" uniqKey="Kalenik B">BM Kalenik</name></author><author><name sortKey="G Ra Sochacka, A" uniqKey="G Ra Sochacka A">A Góra-Sochacka</name></author><author><name sortKey="Sirko, A" uniqKey="Sirko A">A Sirko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Careddu, D" uniqKey="Careddu D">D Careddu</name></author><author><name sortKey="Pettenazzo, A" uniqKey="Pettenazzo A">A Pettenazzo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Fang, Lei" sort="Fang, Lei" uniqKey="Fang L" first="Lei" last="Fang">Lei Fang</name><name sortKey="Roth, Michael" sort="Roth, Michael" uniqKey="Roth M" first="Michael" last="Roth">Michael Roth</name><name sortKey="Stolz, Daiana" sort="Stolz, Daiana" uniqKey="Stolz D" first="Daiana" last="Stolz">Daiana Stolz</name><name sortKey="Tamm, Michael" sort="Tamm, Michael" uniqKey="Tamm M" first="Michael" last="Tamm">Michael Tamm</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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